Endocrine Abstracts

Finding novel drugs and repurposing existing ones have gained increasing attention in addressing various setbacks faced by researchers in cancer research and treatment owing to the increased cancer rate, low efficacy, availability, and affordability of cancer drugs. Thus, the goal of this research is to repurpose nandrolone (ND), an inexpensive and widely available anabolic steroid, to a potential anticancer therapeutic candidate. A computer-aided drug design approach (CADD) i...

Alzheimer’s disease (AD) development has a direct relationship with Brain-insulin resistance. Central in the pathology of AD are beta-amyloid and tau proteins associated with cognitive decline in the hippocampus. Allium sativum L. has been shown to have a neuroprotective effect. Thirty-two male Wistar rats (80-150 g) were assigned into A-D (n=8 each), and housed in standard plastic cages at 23± 1°C. Group A received saline, groups B and C were ad...

Cognitive impairment and neurodegeneration are a few hallmarks of brain insulin resistance, a core feature of Type 2 diabetes mellitus (T2DM). Using a Wistar rat model of a high-fat diet and streptozotocin-induced T2DM, we aimed to determine the potential of Vernonia amygdalina (VA) as a possible treatment for the accompanied neurodegenerative effects of this condition on hippocampal structure and function. T2DM adult rats were prepared by a combination of a high-fat diet and ...